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| − | File:TMEM229 b|Annotated diagram of the TMEM229b gene (with its 3 exons), mature mRNA and protein domains. | + | |
| + | File:TMEM229_b|Annotated diagram of the TMEM229b gene (with its 3 exons), mature mRNA and protein domains. | ||
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Latest revision as of 19:31, 8 May 2012
| Transmembrane protein 229B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | TMEM229B; C14orf83 | ||||||||
| External IDs | HomoloGene: 18700 GeneCards: TMEM229B Gene | ||||||||
| |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 161145 | 268567 | |||||||
| Ensembl | ENSG00000198133 | ENSMUSG00000046157 | |||||||
| UniProt | Q8NBD8 | Q8BFQ2 | |||||||
| RefSeq (mRNA) | NM_182526.2 | NM_001170401.1 | |||||||
| RefSeq (protein) | NP_872332.1 | NP_001163872.1 | |||||||
| Location (UCSC) | Chr 14: 67.91 – 68 Mb | Chr 12: 80.06 – 80.11 Mb | |||||||
| PubMed search | [1] | [2] | |||||||
Transmembrane protein 229b is a protein that in humans is encoded by the TMEM229b gene.[1]
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Contents |
[edit] Nomenclature
The TMEM229B gene is also known as C14orf83, FLJ33387, Q8NBD8, Hs.509707, Hs.712258, IPR010540, and CN083_HUMAN.[2][3][4]
The TMEM229B gene is located on the sense strand (-) of chromosome 14 at location 14q24.1 and spans the chromosomal locus 67,936,983—67,982,021.[5] Covering a total of 45,038 base pairs (bp) along the chromosome, the TMEM229B gene has a total of 3 exons in its primary unspliced transcript mRNA of 4,068 bp. There are a total of 7 transcript variants for TMEM229B ranging in mRNA size from 519 bp to 5008 bp.[6] The TMEM229B gene is flanked by phosphatidylinotisol glycan anchor class H (PIGH), a protein associated with the endoplasmic reticulum specifically GPI-anchor biosynthesis, and PLEK2 on its left.[1][3] See Figure 1.0.
[edit] Tissue distribution
Expressed Sequence Tag mapping of TMEM229B gene expression indicates that it is ubiquitously expressed throughout the body. TMEM229B is more heavily expressed in the parathyroid, skin, and thyroid tissues, and moderately expressed in bone marrow, trachea, spleen, eye, brain, pancreas, mammary gland, intestine, liver, thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues.[7]
[edit] Protein
The translated TMEM229B protein is a total of 167 amino acids long, with a predicted molecular weight of 19,531 Daltons.[8]
The TMEM229B protein contains a domain of unknown function, part of the domain family DUF1113, spanning from amino acids 87 to 135.[2]
Based on predicted structure TMEM229b is highly resemblant of a connexin subunit.[9]
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TMEM229 b
Annotated diagram of the TMEM229b gene (with its 3 exons), mature mRNA and protein domains.
[edit] Clinical relevance
Expression of the TMEM229B gene increases in several disease states including amelanotic skin melanoma, B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, esophageal carcinoma, gastric carcinoma, glioblastoma, liver carcinoma, lymphoma, melanoma, small cell lung carcinoma, T-cell acute lymphoblastic leukemia, thyroid carcinoma and Wilms tumor as found in several microarray experiments.[9] Over-expression of the TMEM229B gene has not been linked as a causal factor in any of these disease states.
[edit] References
- ^ a b "TMEM229B Gene - GeneCards | T229B Protein". GeneCards V3 - Human Genes | Gene Database. http://www.genecards.org/cgi-bin/carddisp.pl?gene=TMEM229B&search=TMEM229B. Retrieved 2011-04-19.
- ^ a b "Homo sapiens transmembrane protein 229B (TMEM229B), mRNA". National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/nuccore/NM_182526.2. Retrieved 2011-04-19.
- ^ a b "Gene & Protein Summary: TMEM229B". European Bioinformatics Institute. European Molecular Biology Laboratory. http://www.ebi.ac.uk/s4/eyeresult/?node=expression&species=Homo_sapiens&term=Homo+sapiens+TMEM229B&tid=nameOrgENSG00000198133. Retrieved 2011-04-19.
- ^ "Human Gene TMEM229B (uc001xjk.2) Description and Page Index". UCSC Genome Browser. http://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=192776815&hgg_section_method_close=0#method. Retrieved 2011-04-19.
- ^ "Gene: TMEM229B (ENSG00000198133)". The Ensembl Project. European Bioinformatics Institute, European Molecular Biology Laboratory, and Wellcome Trust Sanger Institute. http://useast.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198133;r=14:67936983-67982021;t=ENST00000357461. Retrieved 2011-04-19.
- ^ "AceView synopsis of TMEM229B". AceView. http://www.ncbi.nlm.nih.gov. Retrieved 24 April 2011.
- ^ "EST profile: TMEM229B". UniGene. National Library of Medicine. http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?UGID=724866&TAXID=9606&SEARCH=TMEM229B. Retrieved 24 April 2011.
- ^ "Q8NBD8 (T229B_HUMAN)". UniProtKB. EMBL-EBI. http://www.ebi.ac.uk/s4/redirect/aHR0cDovL3d3dy5lYmkuYWMudWsvczQvZXllcmVzdWx0Lz9ub2RlPXByb3RlaW4mc3BlY2llcz1Ib21vX3NhcGllbnMmdGVybT1Ib21vK3NhcGllbnMrVE1FTTIyOUImdGlkPW5hbWVPcmdFTlNHMDAwMDAxOTgxMzM=/3333A?url=http://www.uniprot.org/uniprot/Q8NBD8.html%23section_terms. Retrieved 2011-04-21.
- ^ a b "Transcription profiling of TMEM229B". EMBL-EBI. European Molecular Biology Laboratory and European Bioinformatics Institute. http://www.ebi.ac.uk/s4/redirect/aHR0cDovL3d3dy5lYmkuYWMudWsvczQvZXllcmVzdWx0Lz9ub2RlPWV4cHJlc3Npb24mc3BlY2llcz1Ib21vX3NhcGllbnMmdGVybT1UTUVNMjI5Qitob21vK3NhcGllbnMmdGlkPW5hbWVPcmdFTlNHMDAwMDAxOTgxMzM=/5D0A6?url=http://www.ebi.ac.uk/gxa/gene/ENSG00000198133?ef%3Ddisease_state. Retrieved 24 April 2011.
Dcljr 09 May, 2012
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Source: http://en.wikipedia.org/w/index.php?title=TMEM229B&diff=491444810&oldid=491444526
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